Every layer of biology — from RNA to protein to cellular morphology — and their spatial and temporal relationships provides unique insights to give a more complete picture of cellular function, signaling, and disease states. However, understanding each of these layers through existing multiomics approaches often requires the use of multiple platforms, multiple samples, and the integration of disparate datasets. Our AVITI24 platform changes that by providing simultaneous multiomic readouts directly from your cells with next day results.
Having the right tools can make all the difference in your research. So, how can AVITI24 accelerate your discoveries? Here are 24 reasons why it’s the platform to take your research to the next level.
1. Dual capabilities: One instrument that does it all — in situ, high dimensional multiomics and next-generation sequencing.
2. Simultaneous high dimensional multiomics: With Teton™ CytoProfiling, you can detect transcripts, proteins (including phospho-proteins), and cell morphology features and understand their spatial and temporal dynamics.
3. High-quality NGS: Industry-leading accuracy and cost-efficiency with Cloudbreak™ sequencing, including flexible throughput options.
4. Innovative avidite base chemistry (ABC) technology: ABC technology was purpose-built for expanded flexibility and integrated multiomic readouts.
5. Visualize cellular morphology: Onboard, automated cell paint for 6 morphology features with reversible cell labels to enable multiplex feature detection.
6. Map protein expression: Detect 50+ cell surface, intracellular, and phosphorylated proteins with automated onboard antibody binding, amplification, and detection. See how we mapped drug responses in a model system with high-plex protein detection.
7. Profile RNA transcripts: Subcellular spatial detection of 350+ transcripts with batched detection of 1000s of transcripts per cell.
8. Increased sequencing power*: Achieve up to 3B reads per dual sided run with 50% greater sequencing output—at no additional kit cost or change to your workflows.
9. Library-prep free: Simply adhere your cells to the flow cell, fix them, and let the onboard detection chemistries do the res
10. Largest imageable area: With 20 cm2 imageable area in one dual-sided run, you can analyze more cells without the need for field-of-view selection.
11. Next-day results: Ultra-fast run times with less than 1 hour of off-instrument sample preparation and <24 hour instrument run times.
12. Automated, onboard detection: No need to incubate your sample with antibodies, probes, or other labels—protein, RNA, and cell morphology detection happens on board the instrument, so sample prep is less than an hour of hands-on time.
13. Industry-leading throughput: Process up to 2 million adherent cells per dual sided run and get full multiomic information about your cells in just one day.
14. Flexible sample inputs: Compatible with diverse sample types, including immortalized cell lines, primary cell lines, co-cultures, and cell suspensions.*
15. Multiple well configurations: Flexible flow cell configurations including 1 well, 12 well, or 48 well* so you can look at more samples, more timepoints, or more treatments in one experiment.
16. Curated pre-designed panels: Pre-designed panels for high-plex RNA and protein detection containing validated, biologically relevant targets to address your research questions.
17. Customization capabilities*: Build custom panels tailored to your specific experimental needs. Rapid protein customization requires no oligo conjugation to reduce complexity.
18. Sensitive and dynamic detection: Multiple rounds of sequencing enable detection of RNA and proteins with exceptional sensitivity—up to 1000s of counts per cell.
19. Subcellular, spatial resolution: Resolve thousands of RNA and protein counts per cell with spatial detail at sub-250 nm resolution.
20. Direct in sample sequencing*: High quality, in situ sequencing of whole transcriptome or targeted RNA transcripts. Learn about our novel DiSS chemistry and how we used it TCR screening and optical pooled screening applications.
21. Streamlined software tools: End-to-end software support, including cloud-based analysis, real-time monitoring, compatibility with community tools, and intuitive visualization tools for Teton™ assays.
22. Dual sided runs: Dual independent flow cells enable concurrent Teton CytoProfiling and sequencing runs with independent run starts for maximum flexibility.
23. Future-ready: AVITI24 is built to evolve with continued innovation, expanding capabilities and sample compatibility, without the need to replace the platform.
24. Comprehensive service and support: Backed by a dedicated service and support team ready to assist with fast turnaround times and scientific guidance.
AVITI24 brings together flexibility and speed to deliver unparalleled biological insights so you can get the most out of your samples and time in the lab. Whether you’re working with complex multiomic datasets, high-quality sequencing, or innovative solutions like direct, in sample sequencing, the AVITI24 platform unlocks more possibilities so you can focus more on discovery and less on experimental workflows.
Learn more about these advancements in our 2025 roadmap showcase available on-demand.
*Expanded capabilities, enhanced sample type compatibility, and additional capabilities available on AVITI24™ in 2025.