Understanding the proteomic landscape of signaling pathways and their modulation by target inhibitors is essential for dissecting cellular responses and identifying potential therapeutic strategies. In this poster, we used deep proteomic mapping with the AVITI24™ platform to investigate TNFα-induced apoptosis and the effects of MAPK pathway inhibition.
Download the poster to see how automated, high-plex protein detection reveals cell-type-specific differences in apoptotic pathway responses to inhibitors. Highlights include:
- High-plex protein detection, empowering simultaneous cell typing, resolution of activation states, single-cell visualization, and tracking of intracellular protein dynamics over time.
- High accuracy of AVITI24 protein and RNA detection when compared to gold-standard assays.
- Identification of key protein and RNA targets involved in cell-type-specific responses, enabling further exploration of potential therapeutic strategies aimed at modulating apoptosis.